Epilepsia y cerebelo
Resumen
Entre las funciones fisiológicas clásicamente atribuidas al cerebelo se encuentra el control del movimiento, la postura y el equilibrio. Los estudios clínicos como los realizados en modelos animales, indican que el cerebelo también participa en la coordinación de movimientos finos, la respuesta ocular, la memoria motora, e incluso la conducta sexual. El cerebelo también ha mostrado ser importante en la etiología de enfermedades del sistema nervioso central, tales como las ataxias cerebelosas y el autismo. Sin embargo, la relación entre la epilepsia y el cerebelo ha sido menos explorada. Por lo tanto, esta revisión recopila y discute los estudios que indican cómo las crisis epilépticas afectan al cerebelo, así como el posible papel modulador de éste en la epilepsia.
Abstract
Movement control, posture and equilibrium are some physiological functions classically attributed to cerebellum. Clinical and experimental evidence has shown that cerebellum also participates in coordination of fine motor skills, ocular response, motor memory and sexual behavior. Cerebellum has shown to be important for the etiology of central nervous system diseases such as cerebellar ataxias and autism. However, the relationship between epilepsy and cerebellum has not been fully explored. This review aims to compile and discuss studies that suggest the effect of seizures on cerebellum as well as the consequences of modifying the cerebellar function on epilepsy.
Key words: Epilepsy; seizures; cerebellum; atrophy; purkinje cells.
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