Alteraciones cognitivas en la epilepsia

Jorge Antonio Martínez Díaz, Viridiana Sánchez Zavaleta, Alejandro Mateos Moreno, Jorge Manuel Suárez-Medellín, María Elena Hernández Aguilar, Gonzalo Aranda Abreu

Resumen


La epilepsia es una enfermedad neurológica asociada con frecuencia a alteraciones cognitivas, las cuales alteran significativamente la calidad de vida de los pacientes. Por lo que, el objetivo de este artículo es brindar un panorama general sobre los múltiples factores implicados en dicha asociación, como son el estrés, la ansiedad, la depresión, los medicamentos y el daño generado por la propia enfermedad. También se mencionan los principales predictores conocidos para desarrollar un deterioro cognitivo durante la epilepsia, como son la edad, la duración y la localización de las crisis. Finalmente se comentan los beneficios de algunos tratamientos anticonvulsivantes sobre la cognición.

 

Abstract

Epilepsy is a neurological disease often associated with cognitive alterations, which significantly alter the quality of life of patients. Therefore, the aim of this article is to provide an overview of the multiple factors involved in this association, such as stress, anxiety, depression, medications and the damage generated by the disease itself. Also mentioned are the main known predictors for developing cognitive impairment during epilepsy, such as age, duration and location of seizures. Finally, the benefits of some anticonvulsant treatments on cognition are discussed.

Keywords: Epilepsy; cognition; depression; anxiety.


Palabras clave


Epilepsia; cognición; depresión; ansiedad.

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Referencias


Moshé SL, Perucca E, Ryvlin P, Tomson T. Epilepsy: new advances. Lancet. 2015; 385(9971): 884-898.

Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N. Prevalence and incidence of epilepsy A systematic review and meta-analysis of international studies. Neurology. 2017; 88(3): 296-303.

González-Osornio G. La evaluación neuropsicológica inicial para la epilepsia infantil. Ciencia & Futuro. 2015; 5(3): 99-119.

Lossius MI, Rønning OM, Slapø GD, Mowinckel P, Gjerstad L. Poststroke Epilepsy: Occurrence and Predictors—A Long‐term Prospective Controlled Study (Akershus Stroke Study). Epilepsia. 2005; 46(8): 1246-1251.

Hwang JY, Aromolaran KA, Zukin RS. Epigenetic mechanisms in stroke and epilepsy. Neuropsychopharmacology. 2013; 38(1): 167-182.

Pitkänen A, Roivainen R, Lukasiuk K. Development of epilepsy after ischaemic stroke. Lancet Neurol. 2016; 15(2): 185-197.

Tanaka T, Ihara M. Post-stroke epilepsy. Neurochem Int. 2017; 107: 219-228.

Zhao Y, Li X, Zhang K, Tong T, Cui R. The Progress of Epilepsy after Stroke. Curr Neuropharmacol. 2018; 16(1): 71-78.

Chin J, Scharfman HE. Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms. Epilepsy Behav. 2013; 26(3): 343-351.

Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013; 70(9): 1158-1166.

Born HA. Seizures in Alzheimer’s disease. Neuroscience. 2015; 286: 251-263.

Horváth A, Szucs A, Barcs G, Noebels JL, Kamondi A. Epileptic seizures in Alzheimer disease: a review. Alzheimer Dis Assoc Disord. 2016; 30(2): 186-192.

Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer's disease: causes and clinical relevance. Lancet Neurol. 2017; 16(4): 311-322.

Pugh MJV, Orman JA, Jaramillo CA, Salinsky MC, Eapen BC, Towne AR, Amuan ME, Roman G, McNamee SD, Kent TA, McMillan KK, Hamid H, Grafman JH. The prevalence of epilepsy and association with traumatic brain injury in veterans of the Afghanistan and Iraq wars. J Head Trauma Rehabil. 2015; 30(1): 29-37.

Keret A, Bennett-Back O, Rosenthal G, Gilboa T, Shweiki M, Shoshan Y, Benifla M. Posttraumatic epilepsy: long-term follow-up of children with mild traumatic brain injury. J Neurosurg Pediatr. 2017; 20(1): 64-70.

Webster KM, Sun M, Crack P, O’Brien TJ, Shultz SR, Semple BD. Inflammation in epileptogenesis after traumatic brain injury. J Neuroinflammation. 2017; 14(1): 10.

Benamer HT, Grosset DG. A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia. 2009; 50(10): 2301-2304.

Bröer S, Käufer C, Haist V, Li L, Gerhauser I, Anjum M, Bankstahl M, Baumgärtner W, Löscher W. Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains. Exp Neurol. 2016; 279: 57-74.

Vezzani A, Fujinami RS, White HS, Preux PM, Blümcke I, Sander JW, Löscher W. Infections, inflammation and epilepsy. Acta Neuropathol. 2016; 131(2): 211-234.

Iourov IY, Vorsanova SG, Kurinnaia OS, Zelenova MA, Silvanovich AP, Yurov YB. Molecular karyotyping by array CGH in a Russian cohort of children with intellectual disability, autism, epilepsy and congenital anomalies. Mol Cytogenet. 2012; 5(1): 46.

Pessoa A, Van der Linden V, Yeargin-Allsopp M, Carvalho MDCG, Ribeiro EM, Van Naarden Braun K, Durkin MS, Pastula DM, Moore JT, Moore CA. Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection. Pediatrics. 2018; 141Suppl 2: 167-179.

Ong MS, Kohane IS, Cai T, Gorman MP, Mandl KD. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol. 2014; 71(5): 569-574.

Martynyuk AE, Ucar DA, Yang DD, Norman WM, Carney PR, Dennis DM, Laipis PJ. (2007). Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels. Epilepsia; 48(6): 1143-1150.

Yildiz Y, Sivri, HS. Inborn Errors of Metabolism as Mimickers of Pediatric Neuropsychiatric Disorders: Phenylketonuria as an Example. Clin Mother Child Health. 2017; 14(255): 2.

Ong MS, Kohane IS, Cai T, Gorman MP, Mandl KD. Population-level evidence for an autoimmune etiology of epilepsy. JAMA Neurol. 2014; 71(5): 569-574.

Rahman Z, Wong CH, Dexter M, Olsson G, Wong M, Gebsky V, Nahar N, Wood A, Byth K, King M, Bleasel AB. Epilepsy in patients with primary brain tumors: the impact on mood, cognition, and HRQOL. Epilepsy Behav. 2015; 48: 88-95.

Ullrich NJ, Pomeroy SL, Kapur K, Manley PE, Goumnerova LC, Loddenkemper T. Incidence, risk factors, and longitudinal outcome of seizures in long‐term survivors of pediatric brain tumors. Epilepsia. 2015; 56(10): 1599-1604.

Kraemer DL, Awad IA. Vascular malformations and epilepsy: clinical considerations and basic mechanisms. Epilepsia. 1994; 35 Suppl 6: 30-43.

Al-Shahi SR. The outlook for adults with epileptic seizure (s) associated with cerebral cavernous malformations or arteriovenous malformations. Epilepsia. 2012; 53 Suppl 4:34–42.

Josephson CB, Rosenow F, Salman RAS. Intracranial vascular malformations and epilepsy. Semin Neurol. 2015; 35(3): 223-234.

Takayama M, Hara K, Matsusue A, Waters B, Ikematsu N, Kashiwagi M, Kubo SI. Giant intracranial arteriovenous malformation as the focus of epileptic seizures. Neuropathology. 2017; 38(2):185-191.

Fisher RS, Van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005; 46(4):470-2.

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014; 55(4): 475–82.

Manford M. Recent advances in epilepsy. J Neurol. 2017; 264(8): 1811-1824.

Devilat M. Historia de la Epilepsia. Rev. chil. epilepsia. 2014; 14(2): 45-47.

Ledoux JE. Cognition versus emotion, again-This time in the brain: a response to Parrott and Schulkin. Cognition & Emotion. 1993; 7(1): 61-64.

López RLR, Carvajal AR, Fraga RV. Presencia de deterioro cognitivo y topografía anátomo-clínica en pacientes con epilepsia en Cienfuegos. Revista Finlay. 2015; 5(1): 34-46.

Helmstaedter C, Witt JA. Epilepsy and cognition–A bidirectional relationship? Seizure. 2017; 49: 83-89.

Ure, J. Deterioro cognitivo en pacientes epilépticos. Rev. argent. neuropsicol. 2004; 2(1): 1-14.

Strauss E, Loring D, Chelune G, Hunter M, Hermann B, Perrine K, Westerveld M, Trenerry M, Barr W. Predicting cognitive impairment in epilepsy: findings from the Bozeman epilepsy consortium. J Clin Exp Neuropsychol. 1995; 17(6): 909-917.

Law N, Benifla M, Rutka J, Smith ML. Verbal memory after temporal lobe epilepsy surgery in children: Do only mesial structures matter? Epilepsia. 2017; 58(2): 291-299.

Breuer LEM, Grevers E, Boon P, Bernas A, Bergmans JWM, Besseling R, Klooster DCW, de Louw A, Mestrom RMC, Vonck K, Zinger S, Aldenkamp AP. Cognitive deterioration in adult epilepsy: Clinical characteristics of “Accelerated Cognitive Ageing”. Acta Neurol Scand. 2017; 136(1): 47-53.

Holmes GL. Cognitive impairment in epilepsy: the role of network abnormalities. Epileptic Disord. 2015; 17(2): 101-116.

Nickels KC, Wirrell EC. Cognitive and Social Outcomes of Epileptic Encephalopathies. Semin Pediatr Neurol. 2017; 24(4):264-275.

Moavero R, Santarone ME, Galasso C, Curatolo P. Cognitive and behavioral effects of new antiepileptic drugs in pediatric epilepsy. Brain Dev. 2017; 39(6):464-469.

Tang Y, Xia W, Yu X, Zhou B, Wu X, Lui S, Luo C, Huang X, Ouyang L, Chen Q, Gong Q, Zhou D. Altered cerebral activity associated with topiramate and its withdrawal in patients with epilepsy with language impairment: An fMRI study using the verb generation task. Epilepsy Behav. 2016; 59:98-104.

Afawi Z, Mandelstam S, Korczyn AD, Kivity S, Walid S, Shalata A, Oliver KL, Corbett M, Gecz J, Berkovic SF, Jackson GD. TBC1D24 mutation associated with focal epilepsy, cognitive impairment and a distinctive cerebro-cerebellar malformation. Epilepsy Res. 2013; 105(1): 240-244.

Lomlomdjian C, Múnera CP, Low DM, Terpiluk V, Solís P, Abusamra V, Kochen S. The right hemisphere’s contribution to discourse processing: A study in temporal lobe epilepsy. Brain Lang. 2017; 171: 31-41.

Jackson DC, Dabbs K, Walker NM, Jones JE, Hsu DA, Stafstrom CE, Seidenberg M, Hermann BP. The neuropsychological and academic substrate of new/recent-onset epilepsies. J Pediatr. 2013; 162(5): 1047-1053.

Bender AC, Natola H, Ndong C, Holmes GL, Scott RC, Lenck-Santini PP. Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis. 2013; 54: 297-307.

Mingarro Castillo M, Carmona de la Morena J, Latre Martínez P, Portilla A, Miguel L. Síndrome de Dravet. Rev Clin Med Fam. 2014; 7(2): 134-136.

Pérez AB. Síndrome de Dravet. Salus. 2015; 19(3): 27-30.

Herranz JL. Repercusión cognitiva de las epilepsias precoces. Rev Neurol. 2007; 44 Suppl 3: 43-45.

Rubinstein M, Westenbroek RE, Frank HY, Jones CJ, Scheuer T, Catterall WA. Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome. Neurobiol Dis. 2015; 73: 106-117.

Gandy M, Sharpe L, Perry KN, Miller L, Thayer Z, Boserio J, Mohamed A. The psychosocial correlates of depressive disorders and suicide risk in people with epilepsy. J Psychosom Res. 2013; 74:227–32.

Salter KA, Prior KN, Bond MJ. Predicting wellbeing among people with epilepsy using illness cognitions. Epilepsy Behav. 2017; 71: 1-6.

Kotwas I, Mcgonigal A, Bastien-Toniazzo M, Bartolomei F, Micoulaud-Franchi JA. Stress regulation in drug-resistant epilepsy. Epilepsy Behav. 2017. 71: 39-50.

Kwon OY, Park SP. Depression and anxiety in people with epilepsy. J Clin Neurol. 2014; 10(3): 175-188.

Gil-Nagel A, Lopez-Munoz F, Serratosa JM, Moncada I, Garcia-Garcia P, Alamo C. Effect of lamotrigine on sexual function in patients with epilepsy. Seizure. 2006; 15(3): 142-149.

Lin CY, Burri A, Fridlund B, Pakpour AH. Female sexual function mediates the effects of medication adherence on quality of life in people with epilepsy. Epilepsy Behav. 2017; 67: 60-65.

Sun L, Peräkylä J, Holm K, Haapasalo J, Lehtimäki K, Ogawa KH, Peltola J, Hartikainen KM. Vagus nerve stimulation improves working memory performance. J Clin Exp Neuropsychol. 2017; 39(10):954-964.

Huang H, Wang J, Zhang J, Luo Z, Li D, Qiu X, Peng Y, Xu Z, Xu P, Xu Z. Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats. Oncotarget. 2017; 8(22):35573-35582.

Boison D. Adenosinergic signaling in epilepsy. Neuropharmacology. 2016; 104:131-139.

Zhou Q, Zhu S, Guo Y, Lian L, Hu Q, Liu X, Xu F, Zhang N, Kang H. Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. Mol Neurobiol. 2018; 55(4):3316-3327.




DOI: https://doi.org/10.25009/eb.v9i22.2536

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